Receptor Tyrosine Kinase
Receptor tyrosine kinases (RTKs) are involved in regulating cellular communication and controlling a wide range of cellular functions.36
Examples of RTK targets involved with immune-related signaling in advanced/metastatic NSCLC include VEGFR, C-MET, AXL, KIT, TYRO3, and MerTK. In preclinical studies, some RTKs were shown to play a role in signaling that promotes growth, survival, and metastasis across cancers and contribute to the immune-suppressive microenvironment of many tumors. Preclinical evidence also showed that some RTKs are associated with immune-suppressive cell proliferation and impact the exhaustion of T cells. Targeting certain RTKs may improve the sensitivity of tumor cells to an immunotherapy.36-42
References
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