Investigational approaches
A spotlight on antibody-drug conjugates (ADCs).
ADCs are a class of agents designed to bind to antigens found on tumor cells to help deliver anti‑tumor drugs to their destination inside the cancer cell. The nuanced differences between ADCs matter and remain areas of active investigation, but may not translate to differences in potential clinical effects.*43,44
ADC technology
ADCs are a class of agents designed to bind to antigens found on tumor cells to help deliver anti‑tumor drugs inside the cancer cell.43,44
Each component of an ADC has an individual role to play that may influence its overall activity. ADCs are composed of 3 key components: an antibody, a linker, and a payload.43,44
*As of July 2022, no ADCs have been approved for use in advanced/metastatic NSCLC.
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